摘要
目的:研究血管内皮生长因子(VEGF)及可溶性血管内皮生长因子受体-1(sFlt-1)在正常早孕和原因不明复发性流产(URSA)患者外周血中水平,探讨VEGF及其可溶性受体sFlt-1与原因不明复发性流产的相关性。方法:采用酶联免疫吸附试验法测定35例原因不明复发性流产胚胎停育患者和35例正常早孕孕妇血清VEGF及其sFlt-1水平。结果:原因不明复发性流产胚胎停育患者血清VEGF及其sFlt-1水平较正常早孕孕妇明显增高,两者差异有统计学意义(P<0.01)。结论:血清VEGF及sFlt-1与原因不明复发性流产具有相关性。
Objective：To research the levels of vascular endothelial growth factor （VEGF） and its soluble receptor-1 （sFlt-1） in peripheral blood of normal women of early pregnancy and women with unexplained recurrent spontaneous abortion （URSA）,explore the correlation between VEGF,sFlt-1 and URSA.Methods：Enzyme linked immunosorbent assay （ELISA） method was used to detect the levels of VEGF and sFlt-1 in serum of 35 cases with URSA and 35 normal women of early pregnancy.Results：The levels of VEGF and sFlt-1 in URSA group were significantly higher than those in normal early pregnancy group （P 0.01）.Conclusion：There is a correlation between VEGF,sFlt-1 in serum and URSA.
出处
《中国妇幼保健》
CAS
北大核心
2010年第29期4258-4259,共2页
Maternal and Child Health Care of China
基金
广西自然科学基金资助项目(0991008)
关键词
血管内皮生长因子
可溶性血管内皮生长因子受体-1
原因不明复发性流产
Vascular endothelial growth factor
Soluble vascular endothelial growth factor receptor-1
Unexplained recurrent spontaneous abortion
