摘要
目的:探讨血浆VEGF在异位妊娠早期诊断中的价值,及其与临床类型的关系,寻找指导诊断及治疗新的生化指标。方法:用双抗体夹心酶联免疫吸附法(ELISA)检测75例异位妊娠患者、62例正常宫内早孕及50例异常宫内妊娠患者血浆VEGF含量,同时检测各组血浆孕酮、血清β-HCG。结果:异位妊娠患者血浆VEGF含量[(98.06±93.30)pg/ml]明显高于对照组(15.80±12.38)、(22.45±31.50)pg/ml〗,P<0.05,且患者血浆VEGF升高与患者血清HCG呈线性负相关;间质部异位妊娠血浆VEGF含量为(11.16±8.75)pg/ml,低于其他部位异位妊娠VEGF含量(101.06±93.30)pg/ml;流产型异位妊娠患者血浆VEGF含量〔(109.06±91.30)pg/ml〕明显高于活胚胎组〔(35.25±21.54)、(40.25±23.08)pg/ml〕,P<0.05。结论:患者血浆VEGF含量可作为异位妊娠早期诊断的新的辅助生化指标;患者血浆VEGF含量与临床异位妊娠类型相关,可作为了解病情、判断预后的指标之一。
Objective：Discussing the clinical significance of plasma VEGF in early diagnosis of ecotopic pregnancy and analyzing the relationship between plasma VEGF and the clinical type,to search for the new chemical indicator that helpful in guiding the diagnosis and treatment.Methods：The VEGF,progesterone,β-HCG of 187 cases based on double-antibody sandwich enzyme linked immunosorbent assay were tested,including 75 EP cases,50 cases of abnormal intrauterine pregnancies,and 62 cases of normal intrauterine pregnancies （IUP）.Results：The value of plasma VEGF of EP group 〔（98.06 ±93.30） pg/ml〕was significantly higher than that of control groups which were 〔（15.80 ± 12.38） （22.45 ± 31.50） ng/L〕respectively （P 0.05）.The levels of plasma VEGF of EP were negatively correlated with β-HCG levels.The levels of plasma VEGF of interstitial portion EP,（11.16 ± 08.75） pg/ml were lower than that of other EPs which were （101.06 ± 93.30） pg/ml.The levels of plasma VEGF of abortion EP,（109.06 ± 91.30） pg/ml were much higher than that of living embryos EPs which were （35.25 ± 21.54） pg/ml and （40.25 ± 23.08） pg/ml,P 0.05.Conclusion：The plasma VEGF can be considered as an important indicator in early diagnosis of ectopic pregnancy and treatment evaluation.The plasma VEGF is related to the type of ectopic pregnancy,it can be used to understand the pathogenetic condition and prognosis as one of the indicators
出处
《中国妇幼保健》
CAS
北大核心
2010年第28期4070-4073,共4页
Maternal and Child Health Care of China
基金
深圳市科技和信息局科技计划项目〔200903256〕
关键词
异位妊娠
正常宫内妊娠
异常宫内妊娠
VEGF
Ectopic pregnancy
Normal intrauterine pregnancies
Abnormal intrauterine pregnancies
VEGF
