摘要
目的 :探讨血清孕酮在异位妊娠诊断和治疗中的价值。方法 :选择确诊的异位妊娠病人 39例及正常宫内妊娠者 37例 ,检测并比较两组病人血清孕酮值。用受试者工作特性曲线 (receiver operator characteristic curve,ROC)来确定用于诊断异位妊娠的血清孕酮临界值 (cutoff point)。在 39例病人中 ,选择 2 8例给予甲氨喋呤 (MTX)治疗 ,观察在治疗过程中孕酮降至正常值以下所需要的时间和人绒毛膜促性腺激素 (human chorionic gonadotropin,h CG)降至正常值以下所需要的时间。结果 :1正常宫内妊娠的血清孕酮值显著高于异位妊娠 (P<0 .0 1)。 2推荐以 5 6 nmol/ L 作为血清孕酮诊断异位妊娠的临界值。 3在 MTX治疗成功的病人中 ,血清孕酮降至正常水平以下的时间显著短于血 h CG降至正常水平以下的时间 (P<0 .0 1)。结论 :异位妊娠的血清孕酮值显著低于正常宫内妊娠 ,其检测简便、快捷 ,可以作为一种早期诊断异位妊娠的手段。在治疗异位妊娠的过程中 ,孕酮降至正常的时间显著短于 h CG降至正常的时间 。
Objectives:To probe the value of the serum progesterone in the diagnosis and treatment of ectopic pregnancy(EP).Methods:We choose 39 patients which are diagnosed as EP and 37 normal intrauterine pregnancies(IUP)to involve our study.All patients had serum progesterone measured prospectively.Receiver operator characteristic curve(ROC)was used to determine the cutoff point of progesterone in diagnosing EP.We choose 28 patients from the Eps to give methotrexate treatment and investigate the time required for serum progesterone and for human chorionic gonadotropin(hCG)to decrease to less than normal.Results:①The value of serum progesterone of EPs is lower than that of IUPs significantly( P <0 01).②We recommend 56nmol/L as the cutoff point of progesterone concentrations in diagnosis of EP.③Among the patients with methotrexate treatment,the time required for serum progesterone to decrease to less than normal is significantly less than required for hCG( P <0 01).Conclusion:The serum progesterone can be considered as an early diagnostic method of EP because it can be measured easily and quickly.Because its return to normal values occurs more rapidly than that of hCG levels,serum progesterone can also be a better marker for predicting successful treatment of EP.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2001年第6期343-345,共3页
Journal of Practical Obstetrics and Gynecology
关键词
异位妊娠
血清孕酮
诊断
治疗
Ectopic pregnancy
Serum progesterone
Diagnosis
Treatment
