摘要
目的：研究知母的化学成分，寻找新的活性物质。方法：利用大孔树脂柱色谱、硅胶柱色谱及高效液相色谱等手段进行分离，根据化合物的理化性质及光谱（ＩＲ，ＦＡＢＭＳ，ＥＳＩＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ，ＤＥＰＴ，ＨＭＱＣ，ＨＭＢＣ，ＮＯＥＳＹ和ＲＯＥＳＹ）数据鉴定结构。结果：从中药知母分离得到两种甾体皂苷，确定其结构是：（５β，２５Ｓ）螺甾烷３β，１５α，２３α三醇３ＯβＤ吡喃葡萄糖基（１→２）βＤ吡喃半乳糖苷（１）和（５β，２５Ｓ）螺甾烷３β，２３α二醇３ＯβＤ吡喃葡萄糖基（１→２）βＤ吡喃半乳糖苷（２）。结论：１和２均是新化合物，分别命名为知母皂苷Ｆ和知母皂苷Ｇ。
AIM: To investigate the constituents of the rhizomes of Anemarrhena asphodeloides Bge. and look for new active compounds. METHODS: Compounds were isolated with porous resin, silica gel, HPLC and so on, and identified by chemical and spectroscopic evidence. RESULTS: Two steroidal saponins were obtained, and their structures were shown to be (5,25S)spirostan3,15,23triol3ODglucopyranosyl(12)Dgalactopyranoside ( 1 ) and (5,25S)spirostan3,23diol3ODglucopyranosyl(12)Dgalactopyranoside ( 2 ). CONCLUSION: They were new compounds, named as timosaponinF ( 1 Z) and timosaponinG ( 2 ), respectively.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第6期451-453,共3页
Acta Pharmaceutica Sinica
关键词
知母
知母皂苷F
知母皂苷G
化学成分
Anemarrhena asphodeloides Bge.
timosaponinF
timosaponinG
