摘要
目的:研究桂枝甘草汤"辛甘化阳"配伍的药效及药效作用机理。方法:将实验动物随机分为生理盐水对照组、不同配伍组(桂枝组、甘草组、桂枝甘草汤组),通过抗血栓形成、抗血小板聚集、血小板释放功能(6-keto-PEG1α、TXB2cAMP,cGMP)、血小板胞浆游离钙浓度等实验,研究不同配伍抗血栓的药效及作用机理。结果:桂枝甘草汤与桂枝组、甘草组比较,可显著抑制ADP诱导的血小板聚集,降低大鼠体外血栓湿质量和干质量,增高血小板6-keto-PEG1α水平,降低cGMP水平及钙离子的浓度。结论:桂枝甘草汤通过抑制血小板聚集及释放而发挥其抗血栓作用,表明桂枝配伍甘草,辛甘化阳,能增强温经通脉的作用。
Objective： To investigate the pharmacodynamic action and the mechanism of the compatibility of ＂warming yang with pungent and sweet nature＂ function in Guizhigancao Decoction.Methods：SD rats were divided randomly into four groups：normal control group,guizhi group,gancao group,and guzhi-gancao group.The function of platelet aggregation and release,the contents of 6-keto-PEG1α、TXB2,cAMP,cGMP and dissociative calcium ion were detected to verify the effects.Results：Guzhi-gancao group had obvious effects on inducing platelet aggregationby inhibiting ADP,decreasing both wet weight and dry weight of thrombus in vitro,increasing thrombosis and the contents of 6-keto-PEG1α,and decreasing concentrations of cGMP and calcium ion.Conclusion：Compatibility of Guizhigancao Decoction can enhance the function of invigoration pulse beat through ＂warming yang with pungent and sweet nature＂.
出处
《中药材》
CAS
CSCD
北大核心
2010年第8期1296-1299,共4页
Journal of Chinese Medicinal Materials
基金
广州中医药大学创新基金(K0050097)
关键词
桂枝甘草汤
辛甘化阳
配伍
Guizhigancao Decoctiom
Warming yang with pungent and sweet nature
Compatibility
