摘要
探讨了慢性肺心病（ＣＰＨＤ）急性加重期及经治疗缓解后血清白细胞介素－８（ＩＬ－８）和肿瘤坏死因子－α（ＴＮＦ－α）水平的变化．用双抗体夹心ＥＬＩＳＡ法检测了３０例ＣＰＨＤ患者急性加重期及治疗缓解后血清ＩＬ－８和ＴＮＦ－α，并与相应年龄的健康对照组比较．结果发现ＣＰＨＤ患者急性加重期血清ＩＬ－８及ＴＮＦ－α水平显著高于正常对照组（Ｐ＜０．０５），且治疗缓解后血清ＴＮＦ－α水平显著降低（Ｐ＜０．０５），而血清ＩＬ－８水平则基本不变（Ｐ＞０．０５）．说明ＩＬ－８、ＴＮＦ－α参与了ＣＰＨＤ的发生和发展，这为探求治疗新途径提供了依据．
To explore the change of serum levels of tumor necrosis factor α(TNF α) and interleukin 8(IL 8) and their significance in patients with chronic pulmonary heart disease (CPHD) during attacks and at remission.The levels of serum TNF α and IL 8 were measured with enzyme linked immunosorbent assay (ELISA) in 30 patients with CPHD during attacks and at remission and compared with those in normal controls with the same age.The serum levels of TNF α and IL 8 in patients with CPHD during attacks and at remission were obviously higher than those in normal controls( P <0.05).The level of TNF α was reduced when compared with the attack period( P <0.05) at remission while the level of IL 8 was almost kept constant( P >0.05).TNF α and IL 8 were closely correlated with the formation and development of CPHD and the result provided a basis for obtaining a new therapy for CPHD.
出处
《科技通报》
1999年第3期170-172,共3页
Bulletin of Science and Technology
基金
浙江大学曹光彪高科技基金
