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慢性阻塞性肺疾病患者血清白细胞介素-8的测定及临床意义 被引量:5

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摘要 目的:探讨白细胞介素-8(IL-8)和炎症细胞在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法:收集46例急性加重期、40例缓解期COPD患者、20名健康吸烟者和20名健康不吸烟者的血清,并用放射免疫法测定血清中IL-8。结果:COPD急性加重期及缓解期患者血清IL-8水平明显高于健康对照组,COPD急性加重期又明显高于缓解期,差异有显著性(P<0.01),健康对照组中吸烟者血清IL-8水平明显高于不吸烟者,差异有显著性(P<0.01)。结论:IL-8和中性粒细胞共同参与了COPD气道炎症反应并导致气流阻塞的形成。
出处 《承德医学院学报》 2006年第1期27-29,共3页 Journal of Chengde Medical University
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  • 1Keatings VM,Barnes PJ.Granulocyte activation markers in induced sputum:Comarison between chronic obstructive pulmonary disease,asthma,and normal subjects[J].Am J Respir Crit Care Med,1997,155:449.
  • 2慢性阻塞性肺疾病诊治指南[J].中华结核和呼吸杂志,2002,25(8):453-460. 被引量:5092
  • 3Keatings VM,Jatakanon A,Worsdell YM,et al.Effects of inhaled and oral glucocorticoids on inflammatory induces in asthma and COPD[J].Am J Respir Crit Care Med,1997,155:542.
  • 4Keatings VM,Collins PD,Barnes PJ.Differences in interlukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma[J].Am J Crit Care Med,1996,153:530.
  • 5阳显慧.慢性阻塞性肺疾病患者血清白细胞介素-8的测定及其意义[J].广西医学,1997,19(5):785-786. 被引量:11
  • 6Riise GC,Ahlstedt S,Larsson S,et al.Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronchial lavage fluid[J].Thorax,1995,50:360.
  • 7Schleimer RP,Benenati SV,Friedman B,et al.Do cytokines play a role in leukocyte recruitment and activation in the lungs[J].Am Rev Respir Dis,1991,143:1169.
  • 8Griffths CEM,Voor hees JJ,Nickoloff BJ.Characterization of intercellular adhesion molecular-1 and HLA-DR expression in normal and inflamed skin:modulation by recombinant interferon and tumor necrosis factor[J].J Am Acad Dermatol,1989,20:617.
  • 9Stefano D,Maestrelli AP,Roggeri A,et al.Upregulation of adhesion molecues in the bronchial[J].Am Rev Respir Crit Care Med,1994,149:803.

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