摘要
目的探讨难治性慢性末端回肠炎(chronic terminal ileitis,CTI)的治疗方法。方法对确诊的CTI患者进行常规治疗:甲硝唑+马来酸曲美布汀+乳酸菌素片。一个疗程结束后内镜检查未治愈者72例再进行随机分组,A组26例继续以上治疗,B组26例用巴柳氮钠/柳氮磺胺吡啶+马来酸曲美布汀治疗,C组20例在B组基础上加用小剂量文拉法辛,观察疗效并进行三组对比分析。结果①难治性CTI发生多伴有焦虑、抑郁症状的发生。②C组治疗方法在腹痛、腹泻、右下腹痛等症状、体征改善上均优于A组(P<0.05),与B组无明显差异(P>0.05)。③C组治疗方法在内镜及病理学改善上均明显优于A组(P=0.000),与B组无明显差异(P>0.05)。结论巴柳氮钠/柳氮磺胺吡啶+马来酸曲美布汀在治疗难治性慢性末端回肠炎上疗效优于三联疗法,如伴有焦虑、抑郁障碍加用抗焦虑、抑郁药物疗效更好。
Objective To discuss the treatment method of the difficult chronic terminal ileitis （CTI）.Methods Patients with CTI underwent the conventional treatment： metronidazole ＋ trimebutine maleate tablets ＋ lactein tablets. After a treatment course, these patients accepted the mirror inspection. Seventy-two un-cured patients were randomly divided into group A （26 cases, continuing the above treatment）, group B （26 cases, carrying on the treatment of balsalazide disodium/sulfasalazine ＋ trimebutine maleate tablets）, and group C （20 cases, adding small dosage venlafaxine based on the treatment of group B）. Curative effect were observed and analysed. Results ① The occurrence of difficult CTI was usually accompanied by anxiety and depression. ② In group C, the improvement in the symptoms and physical signs including abdominal pain, diarrhea and right hypogastralgia was better than group A （P0.05） and not significantly different compared with group B （P0.05）. ③ Examination results observed by the mirror and the pathology indicated that the improvement of group C was better than group A （P=0.000） and not significantly different compared with group B （P0.05）. Conclusion The curative effect of balsalazide disodium/sulfasalazine ＋ trimebutine maleate tablets surpassed the triple therapies in the treatment of difficult chronic terminal ileitis. If accompanying anxiety and depression, the curative effect would be better when adding the anti-anxiety and depression medicine.
出处
《华南国防医学杂志》
CAS
2010年第4期261-263,共3页
Military Medical Journal of South China
关键词
难治性慢性末端回肠炎
焦虑抑郁障碍
疗效
Difficult chronic terminal ileitis
Anxiety and depression
Curative effect
