摘要
采用高效液相色谱（HPLC）外标法,测定雏鸭血浆中头孢噻呋的代谢产物脱氧呋喃甲酰头孢噻呋（DFC）的浓度,运用药动学分析软件3P97分析药-时数据,研究经内服、静脉注射和肌肉注射头孢噻呋后,药物在雏鸭体内的血液动力学特征。结果表明：静脉注射给药,血浆药物浓度-时间数据符合无吸收因素一室开放式模型,主要动力学参数为t1/22.23h,Co27.29μg·mL^-1,k0.30h^-1,Vc0.07L·kg^-1,AUC100.07mg·L^-1·h^-1。内服给药,血浆药物浓度-时间数据符合二室开放式模型,主要动力学参数为t1/2。1.64h,t1/2β26.85h,tmax1.09h,Cmax9.08μg·mL^-1,AUC89.60mg·L^-1·h^-1,生物利用度（F）为89.54%。肌肉注射给药,血浆药物浓度-时间数据符合二室开放式模型,主要动力学参数为t1/2ɑ2.28h,t1/2β14.84h,tmax0.28h,Cmax15.23μg·mL-1,AUC为99.32mg·L-1·h-1,F为99.25%。上述结果表明,头孢噻呋经口服和肌肉注射给药,在雏鸭体内的药动学特征优良,其吸收迅速,半衰期较长,生物利用度高。
The concentration of desfuroyiceftiofur（DFC） which is the metabolites of ceftiofur was detected with high performance liquid chromatogram（HPLC）,and the pharmacokinetics parameters were analyzed with 3P97.The pharmacokinetic characteristics of ceftiofur after intravenous injection were best described by a one-compartment open model,the main pharmacokinetic parameters were as follows： t1/2 2.28 h,Co 27.29 μg·mL^-1,ke 0.30 h^-1,Vc 0.07 L·kg^-1 and AUC 100.07 mg·L^-1·h^-1.After oral administration,the plasma concentration-time data was fitted to a two-compartment open model,and the main pharmacokinetic parameters were as follows： t1/2ɑ 1.64 h,t1/2β 26.85 h,tmax 1.09 h,Cmax 9.08 μg·mL^-1,AUC 89.60 mg·L^-1·h^-1 and the bioavailability 89.54%.The pharmacokinetic characteristics of ceftiofur following intramuscular injection were best described by a two-compartment open model,and the main pharmacokinetic parameters were as follows： t1/2ɑ 2.28 h,t1/2β 14.84 h,tmax 0.28 h,Cmax 15.23 μg·mL^-1,AUC 99.32 mg·L^-1·h^-1 and the bioavailability 99.25%.These results showed that after intramuscular injection and oral administration in ducks,ceftiofur had rapid absorption,extensive distribution,long half-time and high bioavailability.
出处
《沈阳农业大学学报》
CAS
CSCD
北大核心
2010年第3期346-349,共4页
Journal of Shenyang Agricultural University
基金
辽宁省博士启动基金项目(1040175)
