摘要
选用30日龄健康海兰鸡65只,按5mg／kg体重口服给予司帕沙星,定期采样,以高效液相色谱法测定血浆、肝、肾、心、肺和肌肉中司帕沙星的含量,研究司帕沙星在鸡体内的药动学与残留。结果表明:司帕沙星在血液中经时过程符合一级吸收二室开放模型,其主要动力学参数如下:t1／2α0.9585h,t1／2β11.7447h,tmax0,6514 h,Cmax0.5271 μg／ml,AUC1.7908mg／L／h。肾脏、心脏的药时数据符合一级吸收二项指数方程,其主要动力学参数分别为:t1/2Ka0.3733 h、0.1530h,t1／2k1.3007 h、2.1013h,tmax1.01420h、0.6239 h,Cmax2.1104μg／ml、1.6721 μg／ml,AUC6.51764 mg／L／h、6.2286mg／L／h。司帕沙星在肝脏、肺脏、肌肉中的经时过程符合一级吸收三项指数方程,主要动力学参数分别为t1/2α0.3672 h、0.6156 h、1.5835 h,t1/2β3.9998 h、15.0271 h、12.0103h,tmax0.7458 h、0.7322 h、1.3726 h,Cmax4.4709μg／ml、2.5267μg／ml、0.9760μg／ml,AUC20.893 mg／L／h,27.242 mg／L／h、9.7943mg/L/h。建议司帕沙星在鸡体内的休药期为7d。
65 of 30-day-old healthy chickens were selected to study pharmacokinetics and residues of Sparfloxacin by HPLC. The results obtained showed that the blood concentration-time curves after oral administration were best described by a two compartment open model. The main pharmacokinetic parameters were as follows: t1/2α0.958 5 h, t1/2β11.745 h, tmax0.651 4 h, Cmax0.527 1 μg/ml, AUC1.790 8 mg/L/h. The kidney and heart concentration-time curves fitted the biexponential equation with first order absorption. Their main pharmacokinetics parameters were t1/2Ka0.373 3 h, 0.153 0h; t1/2K1.300 7 h, 2.101 3 h; tmax1.042 0h, 0.623 9 h; Cmax2.110 4 μg/ml, 1.672 1 μg/ml; AUC6.576 4 mg/L/h, 6.228 6 mg/L/h. And the liver, lung and muscle concentration-time data were best described by a triexponential equation with the first order absorption. The main pharamacokinetics parameters were as follows: t1/2α0.367 2 h, 0.615 6 h, 1.583 5 h; t1/2β3.999 8 h, 15.027 1 h, 2.010 3 h; tmax0.745 8 h, 0.732 2 h, 1.372 6 h; Cmax4.470 9 μg/ml, 2.526 7 μg/ml, 0.976 0 μg/ml, AUC20.893 mg/L/h, 27.242 mg/L/h, 9.794 3 mg/L/h, respectively. The withdrawal time of Sparfloxacin in chickens were suggested as 7 days.
出处
《现代畜牧兽医》
2004年第11期37-39,共3页
Modern Journal of Animal Husbandry and Veterinary Medicine
