摘要
目的探讨雌激素受体表达与食管鳞状细胞癌临床病理的关系。方法用免疫组织化学方法检测了47例林县食管癌组织中ER的表达。结果47例食管癌标本中，ER阳性者19例，其表达率为40．4％（19／47）；生存期大于5年组与小于5年组相比，ER阳性率为28．6％和57．9％，具有显著性差异（P＜0．05），与性别、癌组织分化程度及有无淋巴结转移无关。结论食管癌可能是雌激素依赖性肿瘤，雌激素受体阳性的食管癌与雌激素受体阴性的食管癌相比，后者的预后较好。
[Purpose] To ascertain relationship between clinical pathological features and estrogen receptor (ER). [Method] Immunohistochemical detection of ER was performed in 47 an of Linxian esophageal squamous cell carcinoma (ESCC). [Results] Positive ER was seen in 19 of the 47 patients with esophageal cancer (40.4% ). ER positive was 28. 6% in patient survival longer than 5 years , 57.9% in patient survival less than 5 yare. There was significant difference between the two groups (P < 0. 05.). However, there was no significant correlation with the sex , histologic grade, and lymphatic spread .[Conclusion] It is indicated that carcinogenesis of esophageal carcinoma might be related to sex hormone metablism . The results suggest that ER positive ESCC has worse pronosis than ER negative ESCC.
出处
《中国肿瘤》
CAS
1999年第6期284-285,共2页
China Cancer
基金
河南省自然科学基金!954020900
关键词
雌激素受体
免疫组织化学
食管肿瘤
预后
Estrogen receptor Immunohistochemistry Esophageal neoplasms Squamous cell carcinoma Prognosis
