摘要
应用ＡＢＣ免疫组化法检测１０４例胃癌组织中雌激素受体（ＥＲ），结果ＥＲ阳性率为３４．６％，进展期胃癌ＥＲ阳性率高于早期（Ｐ＜０．０５），分化不良型高于分化型（Ｐ＜０．０５），硬癌型高于髓样型（Ｐ＜０．０５），ＢｏｒｒｍａｎｎⅢ、Ⅳ型高于Ⅰ、Ⅱ型（Ｐ＜０．０５）。提示ＥＲ可作为胃癌生物学行为为恶性程度的标志。１０４例胃癌病人经１～８年随访结果表明，ＥＲ阳性病人根治术后１、３、５年生存率比阴性组低，但无统计学差异。
strogen receptor (ER)
was determined in 104 specimens of human gastric cancer by theavidin-biotion peroxidase
complex (ABC) immunohistochemical method. The result showedthat the over all positive rate
of ER was 34. 6% in gastric cancer, and it was significantlyhigher in advanced than in early
cancer (P<0. 05); in the poordifferentiated than in thewell-differentiated cancer (P<0. 05); in
Borrmann Ⅲ Ⅳ thanⅠⅡ (P<0. 05); in thescrirrhous than in the medullary cancer (P<0. 05); in
the muscle or serosa-invaded than inthe mucosa-invaded (P<0. 05 ,P<0. 01);and in the cancer
with lymph node metastasis thanin those without lymph node metastasis (P<0. 0.05). It is
suggested that ER+ could be usedas a biological indicator of the degree of malignancy for
gastric cancer. The result of follow-up in 104 cases of gastric cancer showed that the survival
rates of the patients with ER+ at 1 ,3,5 years after gastrectomy were lower than those with
negative expression of ER, but with-out statistic significance.
出处
《中国普通外科杂志》
CAS
CSCD
1995年第4期209-211,共3页
China Journal of General Surgery
关键词
胃部肿瘤
雌激素受体
生物学行为
Gastric cancer
Estrogen receptor
Biological characters.
