摘要
本研究采用免疫组化（ＡＢＣ）法，对６６例食管癌组织及２１例正常人食管组织进行雌激素受体（ＥＲ）和孕激素受体（ＰＲ）的检测。结果发现：正常人食管组织不含ＥＲ、ＰＲ；食管癌组织ＥＲ阳性率为４２．４２％（２８／６６），ＰＲ阳性率为４３．９４％（２９／６６）。受体水平与食管癌患者性别、癌分化程度相关，而与年龄、ＴＮＭ分期及有无淋巴结转移无关。结果表明：采用ＡＢＣ法检测石蜡包埋的食管癌组织ＥＲ和ＰＲ具有可靠性和敏感性；检测食管癌ＥＲ、ＰＲ，可为估价预后和指导临床进行内分泌治疗提供参考。
In this Study,estrogen receptor(ER) and progesterone receptor(PR)of cancer tissue and normal esophageal tissue have been detected by immunohisto-chemistry in 66 cases of e esophageal cancer and 21 cases of healthy adults as a control,The results showed that there was no ER and PR in the control group,and the positive rate of Er and PR in cancer group was 42.4%(28/66)and 43.9%(29/66)respectively.The receptor level was closely related to sex,degree of the cancer differentiation,but not to age,TNM stage and lymph node metastasis.Those results suggest that:(1)it is reliable and sensative to Study ER and PR of esophageal cancer tissue with immunohistochemistry assay;(2)It might be useful to study ER and PR of esophageal cancer for evaluating prognosis and guiding postoperative endocrinotherapy after surgery.
出处
《中国胸心血管外科临床杂志》
1995年第1期42-44,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词
食管癌
孕激素受体
免疫组化
雌激素受体
Esophageal cancer
Estrogen receptor
Progesterone receptor
Immunohistochemistry.
