摘要
以外源性高脂大鼠为模型，研究大鼠经高脂饲料喂饲后，心、肝、脑组织脂质过氧化物（ Ｌ Ｐ Ｏ） 及脂褐质的变化，并观察调节源口服液对这两个指标的影响。结果显示，经高脂饲料喂饲的大鼠心肝脑中 Ｌ Ｐ Ｏ 及脂褐质均显著高于正常对照组，而调节源口服液灌胃组对此有明显的拮抗效应。从而表明，高脂饮食可加速大鼠衰老，而调节源口服液则可抗氧化，防衰老。
Lipofuscin and lipid peroxides (LPO) are the characteristic matter showing senium.In this research,we studied the effects of the oral solution of ToGyRun on the lipofuscin and the lipid peroxides of the heart,liver,cerebrum in rats with hyperlipidemia.The results showed that the LPO and the lipofuscin of hyperlipidemia rats were significantly higher than those of the normal control group ( P <0.01).After taking the oral solution of ToGyRun,the LPO of liver and cerebrum could significantly decrease ( P <0.01) and the lipofuscin of heart,liver and cerebrum could also significantly decrease ( P <0.01),but the LPO of heart was an exception.Although it also were decreased,there was not a significant difference.It was indicated that high fat die can accelerate the senium of rats and oral solution of ToGyRun has obvious effects on anti oxidation and reducing the free radical.
出处
《哈尔滨医科大学学报》
CAS
1999年第3期192-194,共3页
Journal of Harbin Medical University
基金
黑龙江省自然科学基金
关键词
调节源口服液
高脂饮食
LPO
脂褐质
衰老
Oral solution of ToGyRun
Lipid peroxidation level
Lipofuscin
High fat die
Senium
Rat
