摘要
研究目的探讨牛磺酸对小鼠心肌脂褐质、脑和肝脏超氧化物歧化酶(SOD)活力的影响,探讨牛磺酸的抗疲劳作用。研究背景机体衰老过程中血脂及脂褐质逐渐升高,SOD下降。有研究表明牛磺酸有一定的降血脂作用,但还不清楚牛磺酸对高脂小鼠体内脂褐质及SOD水平的影响如何。处理方法通过建立高脂血症小鼠模型,观察牛磺酸对小鼠肌脂褐质和小鼠脑及肝脏SOD的影响,观察牛磺酸对正常小鼠游泳疲劳耐受力的影响。结果高血脂小鼠心肌脂褐质含量明显高于牛磺酸组小鼠,两者分别为26.50±5.06μg/g和22.25±0.44μg/g(P<0.05)。高血脂小鼠和牛磺酸小鼠脑组织SOD活力分别为17.79±2.29u/mg和25.98±2.87μ/mg(P<0.01),两组小鼠肝脏组织SOD活力分别为20.14±3.27u/mg和28.93±3.40u/mg(P<0.01)。牛磺酸组小鼠游泳耐受时间较对照组提高101.69％。结论牛磺酸能降低高血脂动物模型心肌脂褐脂含量,增加脑和肝组织SOD活性,并能使动物游泳耐力提高。
Objective To research for the effects oftaurine on the lipofusin content of myocardiumand SOD activities of brain and liver and the phys—ical strengh in mice. Background In the couse of ageing,thereare increace of blood lipid and lipofusin,thedecreace of SOD and physical strength.Thetaurine could decrease the blood lipid,but it isnot clear that if taurine have the same affect onlipofusin,SOD and physical strengh in mice. Methods Through the hyperlipemia modeli11 mice,we studied the effect of taurine on thelipofusin of myocardium,the SOD activities ofbrain and liver and the swimming time in mice. Results The lipofusin of myocardium waslower compared with control group(26.50±5.06and 22.25±4.44pg/g,reepeclively,P<0.05).The SOD activities of liver and brain in taurinegroup was higher than that of hypelipemia mice(尸<0.011,and the swimming time in mice ofthetaurine group was increased 1 0 1.69％than contralgroup(P<0.01). Conclu^on Taurinc can clecrease thelipoflasin and increase SOD activities andenstrength the physical strength.
出处
《新乡医学院学报》
CAS
1993年第4期262-264,共3页
Journal of Xinxiang Medical University
