摘要
目的：探讨TSP-1和VEGF在胃癌微血管生成中的调控作用及临床意义.方法：采用免疫组织化学SP法检测85例胃癌组织（实验组）以及癌缘外≥5 cm远隔胃黏膜组织（对照组）中TSP-1、VEGF和CD31表达水平,研究TSP-1和VEGF的表达与微血管密度（MVD）的相关关系.结果：（1）实验组TSP-1、VEGF阳性率分别为40%（34/85）、81.2%（69/85）,较对照组明显增高（p＜0.01）;（2）TSP-1的表达与MVD呈负相关（p＜0.01）,VEGF的表达与MVD的表达呈正相关（p＜0.01）.结论：胃癌中TSP-1和VEGF的表达与血管新生关系密切,是调控血管生成的重要因素,两者表达平衡决定胃癌新生血管生成.
Objective：To discuss the regulating role and clinical meaning of TSP- 1 and VEGF in microvascularization of gastric cancer. Methods： A total of 85 cases of gastric carcinoma and its normal tissue were studied with SP immunohistochemical technique to evaluate the relation of the expressions of TSP - 1, VEGF with micmvessel density. Results： （ 1 ） 34 cases for TSP - 1 （40%） and 69 cases for VEGF （81.2%） protein were positive respectively . The expression rate of TSP - 1 and VEGF were higher in gastric carcinoma than in its normal gastric tissue（P 〈0.05）. （2）. Gastric carcinoma tissue with a high expression of TSP- 1 showed a low value of MVD while a high expression of VEGF showed a high expression of MVD. Conclusions： （ 1 ） It is suggested that TSP - 1 and VEGF play an important role in neovaseularization and invasive growth in gastric carcinoma. The balance down - expression of TSP - 1 and VEGF is one of the key factors for neovaseularization in gastrie cancer.
出处
《解剖与临床》
2010年第4期246-249,共4页
Anatomy and Clinics
