摘要
目的:研究TSP-1、Survivin、VEGF在骨肉瘤组织中的表达,探讨其与骨肉瘤肺转移的关系。方法:运用免疫组织化学S-P法,检测41例骨肉瘤病例中TSP-1、Survivin、VEGF的表达。结果:①TSP-1、Survivin和VEGF在41例骨肉瘤组织中阳性表达率程度不同。②三者在骨肉瘤组织中的阳性表达与患者的性别、年龄、肿瘤的大小、肿瘤部位、组织学类型、发病时间等因素无相关性(P>0.05),但与是否肺转移显著相关(P<0.05)。③TSP-1与Survivin呈负相关性(r=-0.467,P<0.05);TSP-1与VEGF呈负相关性(r=-0.504,P<0.05)。结论:TSP-1、Survivin和VEGF在骨肉瘤中有着不同程度的表达,与骨肉瘤的发生发展,并与骨肉瘤肺转移密切相关;TSP-1的表达与Survivin、VEGF的表达亦密切相关。
Objective： To study the expressions of TSP-1, Survivin and VEGF in tissues of osteosarcoma and its association with lung metastasis. Method： Expressions of TSP-1, Survivin and VEGF were detected with immunohistochemical staining （SP method） in 41 cases. Result： Positive expression rates of TSP-1, Survivin and VEGF in tissues of osteosarcoma were different. Positive expressions of TSP-1, Survivin and VEGF showed no relevance to the gender, age, the size and location of tumor, types of tissue and onset time （P〉0.05）, but had close relevance to lung metastasis （P〈0.05）. TSP-1 and Survivin suggested a negative correlation （r=-0.467, P〈0.05）; TSP-1 and VEGF also did （r=-0.467, P〈0.05）. Conclusion： Expressions ofTSP-1, Survivin and VEGF are different in osteosarcoma and have close associations to the development of osteosarcoma and lung metastasis; expression of TSP-1 is closely related to expressions of Survivin and VEGF.
出处
《西部中医药》
2012年第6期102-105,共4页
Western Journal of Traditional Chinese Medicine
基金
甘肃省技术研究与开发专项计划项目(编号0709TCYA027)
