摘要
目的:研究乳痛宁颗粒的最佳制粒处方组成。方法:以颗粒吸湿百分率、成型率和溶化率为指标,筛选颗粒最佳辅料与配比。结果:处方最佳组成为1份浸膏粉加1.5份蔗糖。所制颗粒吸湿性小、成型率高、溶解性好、成本低,临界相对湿度约为65%。结论:本研究可为乳痛宁颗粒制剂处方组成的确定及生产环境的控制提供理论依据。
OBJECTIVE： To study optimal formulation process of Rutongning granule. METHODS： The ratio of main components to excipients was optimized with hygroscopicity,granulation and dissolubility index. RESULTS： The optimal ratio of extract powder to saccharose was 1 ∶ 1.5. The made granules were characterized with low hygroscopicity, high granulation,high dissolubility and low cost. And its critical relative humidity was 65%. CONCLUSION： The study provides theory evidence for formulation process of Rutongning granule and the control of production environment.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第31期2914-2915,共2页
China Pharmacy
关键词
乳痛宁颗粒
成型工艺
临界相对湿度
Rutongning granule
Formulation process
Critical relative humidity
