摘要
目的探讨文拉法辛治疗首次抑郁发作的疗效与不良反应。方法 102例首次抑郁发作患者随机平分为文拉法辛组和帕罗西汀组,每组51例。两组分别给予文拉法辛与帕罗西汀治疗,疗程8周。采用汉密尔顿抑郁量表(HAMD)、治疗中出现的症状量表(TESS)评定疗效及不良反应。结果治疗后两组HAMD评分均较治疗前有显著降低(P<0.01);治疗2周末文拉法辛组显著低于帕罗西汀组(χ2=7.121,P<0.01);两组中重度抑郁患者(HAMD>24分)治疗后HAMD评分仍以文拉法辛组显著为低(t=2.25,P<0.05);两组间比较差异无统计学意义(P>0.05)。结论文拉法辛起效快,对重度抑郁症的疗效明显。
Objective Evaluate therapeutic effect of venlafaxine in the treatment of first depression and adverse reactions.Methods 102 patients with first depression were randomly divided into two groups,51 cases in group A were treated with venlafaxine,and 51 cases in group B were treated with paroxetine.With Hamilton Depression Rating Scale（HAMD）,Treatment Emergent Symptom Scale appears（TESS） assessed efficacy and adverse reactions.Results HAMD score was significantly reduced than before treatment in two groups （P0.01）.After 2 weeks of treatment,HAMD score of group A was significantly lower than group B （χ2=7.121,P0.01）.But two groups of patients with moderate to severe depression （HAMD24 points）,after 2 weeks of treatment,HAMD score was no significant difference （P0.05）.Conclusion Venlafaxine have rapid onset of action in severe depression.
出处
《慢性病学杂志》
2010年第8期826-827,共2页
Chronic Pathematology Journal
