摘要
目的:比较西酞普兰与帕罗西汀治疗抑郁症的疗效和安全性。方法:63例抑郁症病人随机分西酞普兰组33例,帕罗西汀组30例,共治疗6周,采用汉密尔顿抑郁量表(HAMD)和临床总体评定量表(CG I)评定临床疗效,采用副反应量表(TESS)评定副反应。结果:西酞普兰组显效率75.8%,帕罗西汀组的显效率73.3%,两组间比较差异无显著性。治疗前后HAMD和CG I-SI评分比较两者均有显著性差异,西酞普兰组在1、2周HAMD减分与帕罗西汀相比有显著性差异。两组副反应TESS评分比较在个别项目上差异有显著性。结论:西酞普兰与帕罗西汀治疗抑郁症均有良好的疗效。其中西酞普兰起效早、副反应轻,是治疗抑郁症的良好药物。
Objective：To explore the effect and security of citalopram and paroxetine. Methods：33 patients with depression were divided into treating group with citalopram, 30 patients with same symptom were divided into controlled group with paroxetine. Clinical progress was examined with HAME - 17, CGI and TESS. Results： There was no significant difference in the efficacy between two groups （ P 〉 0.05 ）. But the effectual time of citalopram was lower remarkably than that of paroxetine group. At every week, there were no significant differences in TESS between two groups. Conclusions ： In the treatment of depression, citalopram and paroxitine all had good curative effects and little side effects. Citalopram took effects quickly and had light side effects.
出处
《中国民康医学》
2005年第9期491-492,共2页
Medical Journal of Chinese People’s Health
