摘要
目的：以ｂ－ＦＧＦ表达为指标，研究与肝细胞癌侵袭性有关的分子机理．方法：应用免疫组化方法研究ｂ－ＦＧＦ在７０例肝细胞癌组织中的表达及其与肝细胞癌侵袭性的关系．结果：ｂ－ＦＧＦ在肝细胞癌组织中表达阳性率为６５．７１％，侵袭性肝癌高于非侵袭性肝癌（Ｐ＜０．０５），不同大小肝癌及不同包膜状况肝癌，其ｂ－ＦＧＦ表达无显著差异，ｂ－ＦＧＦ表达与原发性肝癌的病理分级．ＨＢｓＡｇ和ＡＦＰ无明显关系．结论：ｂ－ＦＧＦ表达可能与肝细胞癌的侵袭性有关．
AIM:b FGF was used as an index to study the molecular mechanism related to the invasiveness of human hepatocellular carcinoma (HCC). METHODS:The expression of b FGF in 70 HCC samples and the relationship between the expression of b FGF and invasiveness of HCC were studied by using an immunohistochemical method. RESULTS:The expression positive rate of b FGF in 70 HCC samples was 65.71%. The expression level of b FGF in HCC samples with invasiveness was higher than that in HCC samples without invasiveness. However, no significant difference in expression of b FGF was found between small and large HCC as well as between HCC with and without capsule. There were no significant correlations between the expression of b FGF in HCC samples and tumor grade,HBsAg and AFP. CONCLUSION:The expression of b FGF was related to the invasiveness of HCC.
出处
《第四军医大学学报》
1999年第4期342-343,共2页
Journal of the Fourth Military Medical University
关键词
肝肿瘤
肝细胞癌
B-FGF
肿瘤侵袭性
liver neoplasms
carcinoma
hepatocellular
basic fibroblast growth factor
neoplasm invasiveness
