摘要
目的：研究云南西双版纳大花哥纳香（ＧｏｎｉｏｔｈａｌａｍｕｓｇｒｉｆｆｉｔｈｉＨｏｏｋ．ｆ．ｅｔＴｈｏｍｓ）茎皮的化学成分。方法：利用各种色谱技术进行分离纯化，根据理化性质和光谱数据等进行结构鉴定。结果：从大花哥纳香茎皮的乙醇提取物中分离得到５个化合物，其结构分别鉴定为５，７二羟基双氢黄酮（Ｉ），５，６２Ｈ６苯乙烯吡喃２酮（ＩＩ），（５Ｒ，６Ｓ，７Ｒ，８Ｒ）７羟基８苯基四氢呋喃骈［３，２ｂ］２Ｈ吡喃２酮（ＩＩ），（６Ｒ，７Ｒ，８Ｒ）６（７，８二羟基苯乙基）５，６２Ｈ吡喃２酮（ＩＶ），（４Ｓ，５Ｒ，６Ｓ，７Ｓ，８Ｒ）６羟基７（α乙酰氧基苄基）四氢呋喃骈［３，２ｂ］呋喃２酮（Ｖ）。初步药理实验表明，化合物ＩＩ～Ｖ有一定的抗肿瘤活性。结论：化合物Ｖ为新化合物，化合物Ｉ和ＩＩ是首次从该植物中分离得到。
AIM: To study the chemical composition in the bark of Goniothalamus griffithii Hook.f.et Thoms. METHODS: Various chromatographic techniques and structural elucidation methods were used to separate and purify the constituents. Their physical and chemical properties and spectral data were measued. RESULTS: Five compounds were isolated from the bark of Goniothalamus griffithii . They were identified as: 5,7 dihydroxyflavanone (I); 5,6 2H 6 styryl 2 pyrone (II); (5R,6S,7R,8R) 7 hydroxy 8 phenyl tetrahydrofuropyran 2 one (III); (6R,7R,8R) 6 (7,8 dihydroxyphenylethyl) 5,6 2H pyran 2 one (IV); (4S,5R,6S,7S,8R) 6 hydroxy 7 (α acetoxybenzyl) tetrahydrofurofuran 2 one (V). CONCLUSION: Compound V is a new compound. Compound II and III were obtained from this plant for the first time. The pharmacological experiments indicated that Sub II～V had the acti cancer activity.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第2期132-134,共3页
Acta Pharmaceutica Sinica
