摘要
目的探讨直肠癌患者免疫状态及其与肿瘤临床病理特征的关系。方法分别采用流式细胞仪和ELISA双抗夹心法检测43例直肠癌患者血清中单个核细胞CD4、CD8以及白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)含量,并与正常人进行对照。结果直肠癌患者外周血T细胞亚群CD4、CD4/CD8明显低于对照组(P<0.01),并且随着Dukes分期的增加而逐渐降低;CD8、IL-8和TNF-α明显高于对照组(P<0.01),并且随着Dukes分期的增加而逐渐升高。结论直肠癌患者存在免疫功能低下,血清中T细胞亚群以及IL-8、TNF-α含量与直肠癌Dukes分期具有相关性。
Objective To investigate the immune status in patients with rectal cancer and the relationship with clinical pathological features. Methods T-cell subgroup CD4, CD8 in mononuclearcells and interleukin-8 （ IL-8 ）, tumor necrosis factor-α（TNF-α） in serum were measured in 43 patients with rectal cancer. Results In rectal cancer, the numbers of CD4, CD4/CD8 were lower than that of control group, but the levels of CDS, IL-8 and TNF-α were higher than those in control group, which changed with Dukes stage. Conclusion The cellular immunity function in patients with rectal cancer significantly decreases, there are correlations between T-cell subgroup, IL-8, and TNF-α and Dukes stage. Therefore, immune therapey should be given in patients with rectal cancer.
出处
《临床肿瘤学杂志》
CAS
2010年第7期631-633,共3页
Chinese Clinical Oncology
关键词
直肠癌
T细胞亚群
IL-8
TNF-Α
Rectal cancer
T-cell subgroup
Interleukin-8
Tumor necrosis faetor-α
