摘要
目的改进硫酸氢氯吡格雷的合成工艺。方法研究了邻氯苯甘氨酸甲酯的合成及拆分,2-氯苯基-2-噻吩乙胺基乙酸甲酯盐酸盐合成新方法,氯吡格雷硫酸氢盐的合成改进等。结果大范围改进了现有氯吡格雷制备工艺,工艺总收率52.5%。结论该工艺操作简便,稳定性好,收率高,适用于工业化生产。
Objective To improve the synthesis of clopidogrel hydrogen sulfate.Methods The synthesis and resolution of o-chlorophenyl glycine methyl ester,a new synthetic method of 2-chlorophenyl-2-thienylethamino methyl acetate hydrochloride and an improved synthesis of clopidogrel hydrogen sulfate were researched.Results The existing preparation process of clopidogrel was modif ied greatly and the total yield of the whole process reached 52.5%.Conclusion This improved process is simple,stable,productive and suitable for the industrial production.
出处
《食品与药品》
CAS
2010年第7期235-237,共3页
Food and Drug
关键词
氯吡格雷
工艺改进
拆分
clopidogrel
process improvement
resolution
