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半乳糖化棕榈酰壳聚糖的制备 被引量：1

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摘要 目的:制备新型的壳聚糖衍生物——半乳糖化棕榈酰壳聚糖。方法:以壳聚糖为原料,甲磺酸条件下与棕榈酰氯反应得两亲性棕榈酰壳聚糖,然后通过与活化乳糖酸反应制备半乳糖化棕榈酰壳聚糖,并应用FT-IR、H1-NMR对其结构进行表征,通过芘荧光探针法测定其临界胶束浓度。结果:半乳糖化棕榈酰壳聚糖的FT-IR及H1-NMR图谱均出现了棕榈酰基的特征峰,且棕榈酰基的取代度为1.8,其临界胶束浓度为8.96μg/mL。结论:制备了新型的半乳糖化棕榈酰壳聚糖,其具有较好的溶解性能和较低的临界胶束浓度,有望作为难溶性药物的主动靶向纳米聚合物胶束载体。
作者 张彦焘 荣利 石春勤 胡巧红
机构地区 广东药学院
出处 《科技创新导报》 2010年第19期18-19,共2页 Science and Technology Innovation Herald
基金 广东省自然科学基金项目(编号8151022401000021) 广东省科技计划项目(编号2009B030801346) 广东药学院师资队伍建设经费资助
关键词 棕榈酰壳聚糖 半乳糖化 聚合物胶束
分类号 TQ46 [化学工程—制药化工]
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参考文献8

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共引文献22

同被引文献8

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科技创新导报
2010年 第19期

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