摘要
观察枢丹的止吐效果及毒副反应。方法：对６０例接受丝裂霉素。顺铂及泰素联合化疗的肺癌患者，采用随机对照的方法比较枢丹和欧必亭在相等剂量下的疗效及毒性。结果：枢丹与欧必亭一样可有效预防化疗所致恶心及呕吐。两药止吐有效率分别为８３．３％及８０．０％，完全缓解率分别为７３．３％及６６．７％，其止吐效果无显著性差异，两药毒副反应均较轻。结论：枢丹为一高效、安全的化疗止吐药。
Objective: To study the anti - emetic effect of Zudan and its toxicity- Methods: A ran-domized study was done in 60 patients with lung cancer who received Mitomycin C, Cisplatin and Taxolchemotherapy comparing the efficacy and the toxicity of identical dosage of Zudan and Navoban. Results:The response rate of emesis induced was 83. 3% in patients receiving Zudan and 80. 0% in those receiv-ing Navoban. Complete response rate was 73. 3% in the Zudan arm and 66. 7% in the Navoban arm.The two arms were not markedly different in response rates. The mild toxicity of the two antiemetics wereobserved. Conclusion: Zudan was safe and effective in the control of chemotherapy induced emesis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第3期214-215,共2页
Chinese Journal of Clinical Oncology
关键词
枢丹
肺肿瘤
药物疗法
呕吐
预防
Zudan
Navoban
Emesis
Lungcancer
Chemotherapy
