摘要
目的：研究雷公藤（ＴｒｉｐｔｅｒｙｇｉｕｍｗｉｌｆｏｒｄｉＨｏｏｋ．ｆ）根心部分化学成分。方法：采用硅胶柱色谱法进行分离，运用现代波谱技术分析鉴定了８个三萜。结果：经光谱鉴定化合物为：雷公藤内酯甲（ｗｉｌｆｏｒｌｉｄｅＡ１），雷公藤内酯乙（ｗｉｌｆｏｒｌｉｄｅＢ２），３ｅｐｉｋａｔｏｎｉｃａｃｉｄ（３），ｃａｎｇｏｒｏｎｉｎｅ（４），ｒｅｇｅｌｉｎ（５），ｓａｌａｓｐｅｒｍｉｃａｃｉｄ（６），３ｈｙｄｒｏｘｙ２ｏｘｏ３ｆｒｉｄｅｌｅｎ２０αｃａｒｂｏｘｙｌｉｃａｃｉｄ（７）以及新化合物３βｈｙｄｒｏｘｙＤ∶Ｂｆｒｉｅｄｏｏｌｅａｎ５∶６ｅｐｏｘｙ２９ｏｉｃａｃｉｄ（８），后者命名为ｔｒｉｐｔｏｔｉｎＣ。结论：化合物８为新化合物。
AIM: To study the active principles of Tripterygium wilfordii Hook f. METHODS: Various column chromatographies with silica gel were employed for the isolation and purification of the ingredients. Their structures were elucidated by spectral analysis. RESULTS: Eight triterpenoids were obtained and were identified as wilforlide A (1), wilforlide B (2), 3 epikatonic acid (3), cangoronine (4), regelin (5), salaspermic acid (6), 3 hydroxy 2 oxo 3 fridelen 20α carboxylic acid (7) and a new compound triptotin C (3β hydroxy D∶B friedoolean 5∶6 epoxy 29 oic acid) (8). CONCLUSION: Compound (8) was a new compound.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第3期210-213,共4页
Acta Pharmaceutica Sinica
基金
国家新药研究重点实验室资助
关键词
雷公藤
三萜
triptotinC
化学成分
Tripterygium wilfordii
triterpenoid
triptotin C (3β hydroxy D∶B friedoolean 5∶6 epoxy 29 oic acid)
