摘要
研究西青果中三萜类化合物对α-葡萄糖苷酶的抑制活性，利用薄层色谱指导柱分离、高效液相色谱结合体外抑制α-葡萄糖苷酶筛选模型的方法进行活性研究。本实验从乙酸乙醅萃取物中分离得到3个三萜类化合物，经鉴定为adunicacid，arjunollcacid，arjungenin，其中arjunicacid（IC50=2．97umol／mL），arjunollc acid（IC50=0．82μmoVmL）具有抑制α-葡萄糖苷酶活性。
In order to recognize α-glucosidase inhibitory ability of triterpenes from the fruits of T. Chebula Retz,the trierpentes were isolated and purified by TLC-guide method and the bioactivity in vitro was investigated by means of the inhibitory activity against to α-GIucosidase combined with HPLC. Three compounds were obtained from the acetic ether extract and identified as arjunic acid,arjunolie acid, arjungenin, among them, arjunic acid （ICso = 2.97 μmol/mL） and arjunolie acid （IC50 = 0.82 μmol/mL） had theability against to α-glueosidase.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第A02期194-196,共3页
Natural Product Research and Development
基金
中药制药过程新技术国家重点实验室资助项目（SK1201020201）
辽宁省高等学校重大科技平台项目（2011-191）
