摘要
目的探讨文拉法辛缓释片与氟西汀治疗脑卒中后抑郁障碍的临床疗效和安全性。方法将58例脑卒中后抑郁障碍患者随机分为两组，每组29例，研究组口服盐酸文拉法辛缓释片治疗，对照组口服氟西汀治疗，观察6周。于治疗前及治疗后1周、2周、4周、6周末采用汉密顿抑郁量表、副反应量表评定临床疗效及不良反应。结果研究组治疗1周末起汉密顿抑郁量表评分较治疗前有显著下降，对照组治疗2周末起有显著下降（P〈0．01）；研究组治疗1周未较对照组下降更显著（P〈0．01），2周、4周、6周末则无显著性差异（P〉0．05）。治疗6周末，研究组显效率82．76％，总有效率100％；对照组分别为79．31％、93．10％，两组无显著性差异（P〉0．05）。研究组不良反应发生率显著低于对照组（x^2=8．861，P＜0．01）。结论盐酸文拉法辛缓释片治疗脑卒中后抑郁疗效显著，且与氟西汀相当，但起效更快、安全性更高、依从性更好，可作为治疗脑卒中后抑郁障碍的一线用药。
Objective To explore the clinical efficacy and safety of venlafaxin hydrochloride sustained-release tablets vs. fluoxetine in the treatment of post-stroke depressive disorder（PSDD）. Methods Fiftyeight PSDD patients were randomized to two groups of 29 ones each, research group took orally venlafaxin hydrochloride sustained-release tablets and control group did fluoxetine 6 weeks. Clinical efficacies were assessed with the Hamilton Depression Rating Scale（HAMD） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the end of the 1st, 2nd , 4th and 6th week. Results Compared with pretreatment, the HAMD score lowered more significantly since the end of the 1st week in the research group and since the end of the 2nd in the control group（P〈0.01）; the HAMD score lowered more significantly at the end of the 1st week in th research than in the control group（P〈0.01）, there were no significant differences between the 2 groups at the end of the 2nd, Ch and 6th week（P〉0.05）. At the end of the 6th week, obvious and total effective rates were 82.76% and 100% in the research and 79.31% and 93.10% in the control group, which showed no significant differences（P〉0.05）. The incidences of adverse reactions were significantly lower in the research than in the control group（x^2=8. 861 ,P〈0. 01）. Conclusion Venlafaxin hydrochloride sustained-release tablets has an obvious therapeutic effect equivelant to fluoxetine on post-stroke depressive disorder,but takes effect more rapidly, has higher safety and cohld be used as the first-line drug in the treatment of post-stroke depressive disorder.
出处
《临床心身疾病杂志》
CAS
2010年第4期318-320,共3页
Journal of Clinical Psychosomatic Diseases
