摘要
白癜风的病因尚不明,国内外研究表明其发生与遗传因素相关,其遗传特征不符合孟德尔遗传规律,而是属于多基因遗传的范畴。主要与人类白细胞抗原HLA-Ⅰ类、Ⅱ类及Ⅲ类基因及其产物相关,以往文献报道认为HLA-Ⅱ类基因与白癜风的关系最为密切。HLA基因的多态性决定HLA分子的多样性。充分认识HLA基因水平的多态性,有助于白癜风的基因诊断和治疗。
The pathogeny of vitiligo is far from clear.The studies indicated that the generation of vitiligo was？relevant to genetic factor.However,its genetic characteristics didn＇t correspond to the rule of Mendelian inheritance,it belongs to polygenic inheritance.It was mainly relevant to HLA-Ⅰ,Ⅱ,Ⅲ alleles and their products.Many reports showed that HLA-Ⅱ alleles had the closest relation with vitiligo.The polymorphism of gene HLA determines the diversity of HLA protein.To investigate the polymorphism of HLA alleles is favorable？to the genetic diagnosis and treatment.
出处
《现代生物医学进展》
CAS
2010年第12期2385-2387,共3页
Progress in Modern Biomedicine
