摘要
目的探讨华东地区汉族HLA-Ⅱ类基因与白癜风的相关性。方法采用聚合酶链反应-序列特异性寡核苷酸探针(PCR-SSOP)方法检测华东地区汉族白癜风患者HLA-DRB1、DQA1和DQB1位点的等位基因。结果与正常人对照组比较,患者DQA103基因频率显著增高(Pc=0.008),而DQA105基因频率显著降低(Pc=0.016)。结论在华东地区汉族人群中,HLA-DQA103、DQA105可能与白癜风相关。
Objective To investigate the association of HLA class Ⅱ genes and vitiligo in the eastern China Han nationality. Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1, DQA1 and DQB1 locus alleles by PCR-SSOP typing. Results The frequency of HLA-DQA1*03 increased significantly (Pc = 0.008) and DQA1*05 decreased significantly (Pc = 0.016) in the patients with vitiligo. Conclusions The results suggest that there exists a correlation between HLA class Ⅱ genes and vitiligo, and DQA1*03 allele may be a susceptible gene or have a close linkage with susceptible genes, while DQA1*05 allele may be a protective gene in the eastern China Han nationality.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2004年第7期408-409,共2页
Chinese Journal of Dermatology
基金
中华医学会皮肤性病学分会皮肤科研究基金(2002年度)
