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吉西他滨单药与吉西他滨和卡培他滨联合化疗对进展期胰腺癌患者疗效的随机Ⅲ期研究 被引量：7

Phase Ⅲ Randomized Comparison of Gemcitabine Versus Gemcitabine plus Capecitabine in Patients with Advanced Pancreatic Cancer
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摘要 1文献来源 David C randomized Gemcitabine , Ian C, Deborah DS, et al. Phase III comparison of Gemcitabine versus plus Capecitabine in patients with advanced pancreatic cancer [J]. J Clin Oncol,2009,27（33）：5513-5518.
作者 杨琼 谢德荣 刘建化
机构地区 中山大学附属孙逸仙纪念医院肿瘤科 广东省人民医院肿瘤中心肿瘤内科 广东省医学科学院
出处 《循证医学》 CSCD 2010年第3期146-149,共4页 The Journal of Evidence-Based Medicine
关键词 胰腺肿瘤 总生存率 吉西他滨 卡培他滨 pancreatic neoplasms overall survival Gemcitabine Capecitabine
分类号 R735.9 [医药卫生—肿瘤]
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参考文献10

  • 1Maisey N,Chau I,Cunningham D,et al.Muhicenter randomized phase Ⅲ trial comparing protracted venous infusion (PVI) Fluorouracil (5-FU) with PVI 5-FU plus mitomycin in inoperable pancreatic cancer[J].J Clin Oncol,2002,20(14):3130-3136.
  • 2Chan I,Cunningham D,Russell C,et al.Gastrazole (JB95008),a novel CCK2/gastrin receptor antagonist,in the treatment of advanced pancreatic cancer:Results from two randomised controlled trials[J].Br J Cancer,2006,94(8):1107-1115.
  • 3Beeck S,Hoehler T,Seipeh G,et al.Capecitabine plus Oxaliplatin (CapOx) versus Capecitabine plus Gemcitabine (CapGem) versus Gemcitabine plus Oxaliplatin (mGemOx):Final results of a multicenter randomized phase Ⅱ trial in advanced pancreatic cancer[J].Ann Oncol,2008,19(2):340-347.
  • 4Stathopoulos GP,Syrigos K,Polyzos A,et al.Front-line treatment of inoperable or metastatic pancreatic cancer with Gemcitabine and Capecitabine:An intergroup,multicenter,phase Ⅱ study[J].Ann Oncol,2004,15(2):224-229.
  • 5Huguet F,Girard N,Guerche CS,et al.Chemoradiotherapy in the management of locally advanced pancreatic carcinoma:A qualitative systematic review[J].J Clin Oncol,2009,27(13):2269-2277.
  • 6Xie DR,Yang Q,Chon DL,et al.Gemcitabine-based Cytotoxic doublets chemotherapy for advanced pancreatic cancer:Updated subgroup meta-analyses of overall survival[J].Jpn J Clin Oncol,2010,40(5):432-441.
  • 7Heinemann V,Boeck S,Hinke A,et al.Meta-analysis of randomized trials:Evaluation of benefit from Gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer[J].BMC Cancer,2008,8:82.
  • 8Scheithauer W,Schüll B,Ulrich-Pur H,et al.Biweekly high-dose Gemcitaine alone or in combination with Capecitsbine in patients with metastatic pancreatic adenocarcinoma:A randomized phase Ⅱ trial[J].Ann Oncol,2003,14(1):97-104.
  • 9Herrmann R,Bodoky G,Ruhstaller T,et al.Gemcitabine plus Capecitabine compared with Gemcitabine alone in advanced pancreatic cancer:A randomized,multicenter,phase Ⅲ trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group[J].J Clin Oncol,2007,25(16):2212-2217.
  • 10Sun JF,Wu RR,Norris C,et al.Safety of chronic low-dose Capecitabine as maintenance therapy in gastrointestinal cancers[J].Gastrointest Cancer Res,2009,3(4):134-140.

同被引文献38

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循证医学
2010年 第3期

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