摘要
目的分析吉西他滨为基础的化疗方案治疗进展期胰腺癌的临床疗效。方法选取在2014年1月至2015年6月期间到我院接受化疗的进展期胰腺癌患者54例,其中21例患者接受吉西他滨单药化疗,将其作为对照组;33例患者接受吉西他滨联合其他药物化疗,将其作为观察组。比较两组患者的临床疗效、生存情况及不良反应。结果观察组患者临床有效率为42.4%,疾病控制率为81.8%,对照组临床有效率为19.0%,疾病控制率为52.4%,两组差异有统计学意义(P<0.05)。两组中位生存时间分别为11.7个月和7.1个月,中位无进展生存时间分别为4.6个月和2.8个月,6个月生存率分别为69.7%和57.1%,两组比较,差异具有统计学意义(P<0.05);观察组对CA199水平的影响优于对照组(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论以吉西他滨为基础的化疗方案治疗进展期胰腺癌,较单药治疗效果更佳,可显著提高患者生存率。
Objective Effect on gemcitabine based chemotherapy regimens for the treatment of advanced pancreatic cancer was investigated. Methods Data were collected from 54 cases with advanced pancreatic cancer undergoing chemotherapy who were treated in our hospital during January 2014 to June 2015 were included. Twentyone patients received gemcitabine single-agent chemotherapy, which was used as the control group,33 patients received gemcitabine combined with other drugs chemotherapy, which was used as the observation group. The clinical efficacy survival circumstances and adverse reactions of the two groups, were compared. Results The clinical effective rate of the observation group was 42.4%, the disease control rates was 81.8%. The clinical effective rate of the control group was 19.0%, disease control rates was 52.4%. The differences between the two groups was statistically significant （P〈0.05）. The median survival time of the two groups was 11.7 months and 7.1 months respectively, the median progressionfree survival time was 4.6 months and 2.8 months, respectively, and the 6 months survival rates were 69.7% and 57.1% respectively.Comparing the two groups, the difference was statistically significant （P〈0.05）.The effect of the observation group on CA199 level was better than that of the control group （P 〈 0.05）. The adverse reactions of the two groups was not statistically significant（P〉0.05）. Conclusion The therapeutic effect of advanced pancreatic cancer with gemcitabine bsed chemotherapy regimens is better than that of a single drug therapy. It can significantly improve patients＇ survival rate.
出处
《北京医学》
CAS
2017年第4期360-363,共4页
Beijing Medical Journal
关键词
吉西他滨
化疗方案
进展期胰腺癌
gemcitabine
chemotherapy regimens
advanced pancreatic cancer
