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化疗联合贝伐单抗及帕尼单抗与化疗单纯联合贝伐单抗在治疗转移性结直肠癌作用中的比较 被引量:24

A Randomized Phase ⅢB Trial of Chemotherapy,Bevacizumab,and Panitumumab Compared with Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer
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摘要 1 文献来源 Hecht JR,Mitchell E,Chidiac T,et al.A randomized phase Ⅲ B trial of chemotherapy, Bevacizumab, and Panitumumab compared with chemotherapy and Bevacizumab alone for metastatic colorectal cancer [J]. J Clin Oncol, 2009, 27(5): 672-680.
作者 沈琳 黎莹
出处 《循证医学》 CSCD 2009年第3期141-143,共3页 The Journal of Evidence-Based Medicine
关键词 转移性结直肠癌 药物疗法 帕尼单抗 贝伐单抗 metastatic colorectal cancer(mCRC) drug therapy Panitumumab Bevacizumab
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参考文献7

  • 1van Cutsem E,Peeters M,Siena S,et al.Open-label,randomized,phase 3 clinical trial of Panitumumab plus best supportive care versus best supportive cave in patients with chemotherapy-refractory metastatic colorectal cancer[J].J Clin Oncol,2007,25:1658-1664.
  • 2Berlin J,Posey J,Tchekmedyian S,et al.Panitumumab with Irinotecan/Leucovorin/5-Fluorouracil for first-line treatment of metastatic colorectal cancer[J].Clin Colorectal Cancer,2007,6:427-432.
  • 3Amado RG,Wolf M,Peeters M,et al.Wildtype KRAS is required for Panitumumab efficacy in patients with metastatic colorectal cancer[J].J Clin Oncal,2008,26:1626-1634.
  • 4Hurwitz H,Fehrenbacher L,Novotny W,et al.Bevacizumab plus Irinotecan,Fluorouracil,and Leucovorin for metastatic colorectal cancer[J].N Engl J Med,2004,350:2335-2342.
  • 5Giantonio BJ,Catalano PJ,Meropol NJ,et al.Bevacizumab in combination with Oxaliplatin,Fluorouracil,and Leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer:Results from the Eastern Cooperative Oncology Group Study E3200[J].J Clin Oncol,2007,25:1539-1544.
  • 6Saltz LB,Lenz HJ,Kindler HL,et al.Randomized phase Ⅱ trial of Cetuximab,Bevacizumab,and Irinotecan compared with Cetuximab and Bevacizumab alone in Irinotecan-refractory colorectal cancer:The BOND-2 study[J].J Clin Oncol,2007,25:4557-4561.
  • 7Tol J,Koopman M,Cats A,et al.Chemotherapy,Bevacizumab,and Cetuximab in metastatic colorectal cancer[J].N Engl J Med,2009,360:563-572.

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