摘要
检测71例不同程度感染幽门螺杆菌(HP)的慢性萎缩性胃炎患者(患者组)和70例健康成人(对照组)血浆-一氧化氮(P-NO)、血浆维生素C(P-VC)、血浆维生素E(P-VE)、血浆β-胡萝卜素(P-β-CAR)、血浆过氧化脂质(P-LPO)含量及红细胞超氧化物歧化酶(E-SOD)、红细胞过氧化氢酶(E-CAT)、红细胞谷胱甘肽过氧化物酶(E-GSH-PX)活性和红细胞过氧化脂质(E-LPO)含量。结果与对照组比较,患者组的P-VC、P-VE、P-β-CAR、E-SOD、E-CAT和E-GSH-PX水平均值均显著降低(P<0.001),且随HP增多而降低;P-NO、P-LPO和E-LPO平均值均显著升高(P<0.001),且随HP增多而升高。并均呈一定程度的直线回归和相关(P<0.001)。提示慢性萎缩性胃炎患者体内的NO代谢异常,氧化和抗氧化平衡严重失调,氧自由基反应和脂质过氧化反应病理性加剧,且与HP检出量呈正相关。
To study the correlation between helicobacter pylori and nitric oxide, oxidation, lipoperoxi-dation in atrophic gastritis. We measured the plasma nitric oxide (P-NO), plasma vitamin C (P-VC), plas-ma vitamin E (P-VE), plasma β-carotene (P-β-CAR), plasma lipoperroxides (P-LPO) contents and ery-throcyte superoxide dismutase (E-SOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxi-dase (E-GSH-PX) activities and erythrocytd lipoperoxides (E-LPO) content in 71 artophic gastritis patients (patient group) and 70 healthy persons (control group). Compared with the control group, the average P-VC, P-VE, P-β-CAR contents and E-SOD, E-CAT, E-GSH-PX activities of patient group decreased clear-ly, and the average P-NO, P-LPO, E-LPO contnets increased clearly (P<0.001), with increase of the number of helicobacter pylori. The metabolism of nitric oxide and the balance betwen oxidation and antioxi-dation in the atrophic gastritis patients were serious imbalanced, oxygen free radical reaction and lipoperoxi-dation reaction were pathologically exacerbated. Acorrelation was demonstrated among the number of heli-cobacter pylori, nitric oxide, oxidation, lipoperoxidation.
出处
《临床消化病杂志》
1999年第1期21-23,共3页
Chinese Journal of Clinical Gastroenterology
