摘要
本文报道给C57小鼠腹腔注射不同剂量1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)后,发现组3(MPTP35 mg/kg,每天一次,共7天)鼠肝匀浆、线粒体和微粒体的膜丙二醛含量明显增加,与对照组相比分别增加70.5%,67%和51.4%(P<0.01),而组1(MPTP 35mg/kg,每4小时一次,共3次)和组2(MPTP35mg/kg,每天一次,共4天)鼠肝丙二醛含量与对照组相近。结果表明MPTP有明显地促进鼠肝脂质过氧化的作用,并与其剂量有关。
The administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) 35 mg/kg daily for 7 days markedly increased hepatic malonaldehyde (MDA) level in C57 mice. Tne increase was 70.5% in hepatic homogenates, 67% in mitochondria and 51.4% in microsomes (P<0.01). However, the use of MPTP 35 mg/kg daily for 4 days or 3 injections of 35 mg/kg at 4 h intervals in a single day did not show the same effect. This result suggests that MPTP can significantly accentuate lipid peroxidation of mouse liver, and that the effcct is dose-dependent.
出处
《上海第二医科大学学报》
CSCD
1990年第3期216-218,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
MPTP
脂质过氧化
肝
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine C57 mouse liver lipid peroxidation
