摘要
大鼠经饮水连续染铅，分利于第１、２、４、６、８周末处死动物，取肾脏测定脂质过氧化的有关指标。结果丙二醛水平在实验１～６周显著升高，且不受还原型谷胱甘肽含量升高和谷胱甘肽过氧化物酶活性的影响。超氧化物歧化酶则经历了先抑制，后升高的变化过程。表明铅能引起大鼠肾组织脂质过氧化，提示Ｏ２·自由基可能是启动这一反应的关键因素。
Lead was continuously admnistrated to
rats by way of drinking water (lead acetate,1500 mg/L).The rats were killed at the end of 1,2,4,6,
8 weeks respectively and kidneys were removed for the mea-suring of the relative indexes of
lipid peroxiuation. Results showed that the level of malondialdehyde(MDA)was significantly
increased in the first 6 weeks and this condition did not been affected by ob-viously elevated
content of glutathion and the activity of glutathion peroxidase. The activity of superox-ide
dismutase varied with the course of time(inhibition in the first 2 weeks and activation at the end
of6 week).The present data demonstrated that lead caused lipid peroxidation in kidney of rats
and sug-gested that O2 might be the key factor of initiating the reaction.
出处
《中国医科大学学报》
CAS
CSCD
1994年第6期565-567,共3页
Journal of China Medical University
