摘要
目的研究胰岛素抵抗在多囊卵巢综合征(PCOS)发病中的作用,运用二甲双胍联合氯米芬治疗多囊卵巢综合征。方法对46例月经稀发或闭经的多囊卵巢综合征患者(治疗组)接受8周二甲双胍治疗。在用药8周后测定血LH、FSH、睾酮及血清胰岛素水平并与对照组比较。结果经用氯米芬治疗1月后有10例诱发排卵,余36例用二甲双胍加用氯米芬再治疗2月后有30例诱发排卵。用药8周后测定血LH、LH/FSH、血清胰岛素、血睾酮有明显下降。结论二甲双胍能改善并诱发排卵功能,并增强高胰岛素血症患者对氯米芬的敏感性,二甲双胍联合氯米芬对有胰岛素抵抗的PCOS患者促排卵治疗具有协同作用,可有效提高排卵率,是一种安全且有效的方法,从而治疗多囊卵巢综合征。
Objective To study the insulin resistance in polycystic ovary syndrome（PCOS） pathogenesis,using dimethyl pairs Amtolmetin treatment of polycystic ovary syndrome.Methods 46 patients with oligomenorrhea or amenorrhea in women with polycystic ovary syndrome（treatment group） received 8 weeks DMBG treatment.In the medication after 8 weeks and serum LH,FSH,testosterone and serum insulin level and compared with the control group.Results After treatment with clomiphene for one month 10 cases of ovulation induction,more than 36 cases of DMBG with clomiphene citrate for two months and 30 cases of ovulation induction.After 8 weeks medication and serum LH,LH/FSH,serum insulin,blood testosterone decreased significantly.Conclusion DMBG and ovulation induction to improve function and enhance hyperinsulinemia patients the sensitivity of clomiphene citrate,metformin combined with clomiphene citrate on insulin resistance in PCOS patients with ovulation induction therapy has synergistic effect,can effectively improve the ovulation rate,is a safe and effective methods to treat women with polycystic ovary syndrome.
出处
《中国实用医药》
2010年第20期63-64,共2页
China Practical Medicine
