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多囊卵巢综合征胰岛素抵抗的研究进展 被引量：2

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摘要 多囊卵巢综合征（PCoS）是育龄妇女最常见的内分泌紊乱性疾病，生育期妇女的发病率为4％～12％，以高雄激素血症和长期不排卵为主要临床特征，B超示双侧卵巢呈多囊改变。PCOS的病因迄今尚不清楚。自1980年Burghen首次提出胰岛素抵抗参与PCOS的发病过程以来，大量的研究证实胰岛素抵抗与PCOS存在密切关系，可能是PCOS的发病原因之一。现就PCOS胰岛素抵抗的研究进展综述如下。
作者 张华 贾伟平
机构地区 上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病研究所
出处 《上海医学》 CAS CSCD 北大核心 2006年第10期754-757,共4页 Shanghai Medical Journal
关键词 多囊卵巢综合征 胰岛素抵抗 内分泌紊乱性疾病 PCOS 高雄激素血症 生育期妇女 育龄妇女 临床特征
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献22

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  • 3王竹晨,顾熊飞,杨冬梓,邝健全.脂肪组织中胰岛素受体底物1蛋白的表达及酪氨酸磷酸化在多囊卵巢综合征发病中的作用[J].中华妇产科杂志,2005,40(2):120-123. 被引量：10
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二级参考文献31

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共引文献46

同被引文献26

  • 1朱雅男,王勇,吴效科.多囊卵巢综合征胰岛素抵抗的分子机制[J].中国实用妇科与产科杂志,2005,21(8):501-503. 被引量：14
  • 2陈子江.高度重视多囊卵巢综合征的规范化诊断与治疗[J].中华妇产科杂志,2007,42(5):289-290. 被引量：69
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  • 7El Mkadem SA,Lautier C,Macari F,et al. Role of allelic variants Gly 972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polyeysfic ovary syndrome[J]. Diabetes, 2001,50(9) : 2164-2168.
  • 8Korhonen S, Heinonen S, HiltunenM, et al. Polymorphism in the peroxisome proliferator activated receptor Y gene in women with polycystic ovary syndrome[J]. Hum Reprod, 2003,18(3) :540-543.
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引证文献2

二级引证文献13

上海医学
2006年 第10期

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