二甲双胍治疗多囊卵巢综合征的临床效果观察被引量：1

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摘要目的:探讨胰岛素增敏剂二甲双胍对多囊卵巢综合征(PCOS)的胰岛素抵抗及排卵的治疗效果。方法:90例月经稀发或闭经的PCOS患者,随机分成3组,30例给予克罗米酚治疗(克罗米酚组),30例给予二甲双胍治疗(二甲双胍组),30例给予二甲双胍及克罗米酚治疗(联合治疗组)。在用药8周后观察二甲双胍组治疗前后体重指数、腰臀比、黄体生成素(LH)、LH与卵泡刺激素(FSH)比值、睾酮及血清胰岛素水平与排卵率的变化。结果:经治疗8周后,二甲双胍组血LH、LH/FSH、睾酮、血清胰岛素水平有明显下降,差异有显著性(P<0.01);二甲双胍组中有12例诱发排卵,克罗米酚组有18例诱发排卵,联合治疗组有27例诱发排卵。结论:二甲双胍能改善并诱发排卵功能,并增强多囊卵巢综合征患者对克罗米酚的敏感性,联合治疗能明显提高排卵率。

作者黄柳鲜

机构地区广西崇左市妇幼保健院妇产科

出处《中国社区医师（医学专业）》 2011年第29期23-24,共2页

关键词多囊卵巢综合征胰岛素抵抗二甲双胍

分类号 R711.7 [医药卫生—妇产科学]

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