摘要
采用Valia-Chien扩散池法,以离体SD大鼠皮肤为渗透屏障,比较青霉素钠经离子导入与被动扩散的透皮速率,并以HPLC法测定皮肤和接收液中青霉素钠的含量。结果表明,离子导入和被动扩散的透皮速率分别为241.02和31.91μg·cm-2·h-1。提示离子导入能促进青霉素钠的经皮吸收(P<0.05),且导入量随着导入时间的延长而增加。以皮内注射为对照,考察了青霉素钠经离子导入在SD大鼠在体皮肤中的滞留情况。结果表明,离子导入组皮肤中的青霉素钠含量[(72.52±22.06)μg/g]与皮内注射组[(54.04±12.31)μg/g]相比无显著性差异(P>0.05)。
The transdermal transport and retention of benzylpenicillin sodium by iontophoresis and passive diffusion were measured by Valia-Chien diffusion cells through excised SD rat skin.The drug concentration was determined by HPLC.The results showed that the permeation rates of iontophoresis and passive diffusion were 241.02 and 31.91 μg·cm^-2·h^-1.It indicated that iontophorsis could promote the penetration absorption of benzylpenicillin sodium（P〈0.05）.And the penetration absorption was increased with iontophoresis time.With the intradermal injection as the control,the transdermal retention of iontophorsis was investigated with SD rat as animal model.The results showed that there was no significant difference in retention between iontophoresis group [（72.52±22.06） μg/g] and intradermal injection group[（54.04±12.31） μg/g]（P〉0.05）.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第7期518-521,共4页
Chinese Journal of Pharmaceuticals
关键词
经皮给药
离子导入
皮试
青霉素钠
transdermal
iontophoresis
cutantest
benzylpenicillin sodium
