摘要
目的探讨联合应用阿托伐他汀和阿昔莫司治疗混合性高脂血症的临床疗效。方法共入选186例混合性高脂血症患者,随机分入阿托伐他汀组(n=52)、阿昔莫司组(n=54)和联合治疗组(阿托伐他汀+阿昔莫司,n=80)。观察治疗前后主要血脂参数的变化幅度以及不良反应。结果联合治疗组血脂参数变化幅度最显著,血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和甘油三酯(TG)均显著下降,而血清高密度脂蛋白胆固醇(HDLC)升高优于阿托伐他汀组和阿昔莫司组(P<0.01)。结论阿昔莫司组与小剂量阿托伐他汀联合治疗可全面调节血脂,有效治疗混合型高脂血症。
Objective To explore the effect of combination of atorvastatin and acipimox in treatment of mixed hyperlipidemia.Methods A total of 186 cases selected patients with mixed hyperlipidemia were randomly divided into atorvastatin group（n=52）,acipimox group（n=54） and the combined treatment group（atorvastatin＋acipimox,n=80）.Observe the change range of the main lipid parameters and adverse reactions.Results Changes in the treatment of lipid parameters increase most significantly,serum total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C） and triglyceride（TG） were significantly decreased.Serum high density lipoprotein cholesterol（HDLC） higher than that of atorvastatin group and acipimox group（P0.01）.Conclusion Acipimox group and low dose atorvastatin combination therapy can fully regulate blood fat,effectively treat mixed hyperlipidemia.
出处
《医药论坛杂志》
2010年第11期1-2,共2页
Journal of Medical Forum
