摘要
【目的】观察辛伐他汀联合阿昔莫司对颈动脉粥样硬化斑块的影响。【方法】117例高脂血症并颈动脉粥样硬化斑块患者并随机分为三组：辛伐他汀组（39例），在常规治疗基础上加辛伐他汀40mg，每晚1次；阿昔莫司组（39例），在常规治疗基础上加阿昔莫司，250mg，每天2次；联合治疗组（39例），在常规治疗基础上加阿昔莫司，每天2次，辛伐他汀40mg，每晚1次。患者均连续服药6个月，并均于服药前和服药后第6个月检查颈动脉粥样硬化斑块大小、血脂水平。【结果】三组患者治疗前后相比较血脂下降、颈动脉斑块消退差异均有显著性（P〈0．05），其中联合用药组血脂变化、颈动脉斑块消退治疗后最为明显，与其他组比较差异有显著性（P〈0．05）。【结论】辛伐他汀联合阿昔莫司能够更有效地消退颈动脉斑块，其效果优于单独应用辛伐他汀或阿昔莫司。
[Objective]To observe the effect of simvastatin combined with acipimox on carotid atheroscle rotic plaques in hyperlipemia patients. [Methods] A total of 117 hyperlipemia patients with carotid atherosclerosis were randomly divided into 3 groups. Simvastatin group received simvastatin 40mg per day. Acipimox group received acipimox 250mg twice a day. Combined group received acipimox 250mg twice a day and simvastatin 40mg per day. The entire treatment lasted for 6 months. All the patients＇ carotid atheroscierotic plaque and the level of blood fat were checked before and after the administration. [Results] At 6 months after treatment, the level of blood fat decreased（ p 〈0.05）, and the area of carotid atherosclerotic plaque became smaller （ P 〈0. 05） in each group, especially in the combined group（ P 〈0.01）. [Conclusion] Simvastatin combined with acipimox is effective for reducing the size of carotid atberosclerosis plaques in hyperlipemia patients, and its efficacy is better than single simvastatin or acipimox treatment.
出处
《医学临床研究》
CAS
2010年第3期425-427,共3页
Journal of Clinical Research
