摘要
目的：探讨胃疡Ⅰ号治疗急性胃粘膜损伤的药理作用。方法：运用胃疡Ⅰ号治疗大鼠急性胃粘膜损伤，观察大鼠血浆内皮素水平、胃粘膜血流速度、ＡＴＰ酶活性、ＡＴＰ含量、病理改变、溃疡指数的变化。结果：治疗组大鼠血浆内皮素水平下降、胃粘膜ＡＴＰ酶活性及ＡＴＰ含量升高、胃粘膜血流速度加快、糜烂出血减少，效果以大剂量组最佳，与模型组相比有显著性差异（ Ｐ＜ ０．０１～０．０５）。结论：胃疡Ⅰ号对大鼠急性胃粘膜损伤有显著的疗效，其机制可能是一种综合效应。
Objective:To study the effect of Weiyang 1 on rats with the acute lesion of gastric mucosa. Method:Treating the experimental rats with Weiyang 1 and observing the paramefers as the plasma endothelin level,velosity of blood in gastric mucosa,the activity of ATP enzyme,content of ATP,pathologic changes and ulcer index.Results:The plasma endothelin level down,the activity of ATP enzyme and content of ATP up in treatment group,and also,the velosity of blood in gastric mucosa becoming faster and the erosion and bleeding improved. The therapeutic effect is best in maximum dose group with significant difference.Conclusion:Weiyang 1 has obvious effect on rafs with acute lesion of gasfric mucosa,and its mechanism may be comprehensive.
