摘要
本文研究了胃痛灵与丽珠得乐保护胃粘膜的作用机理，当酸性乙醇灌胃引起大膜损伤时，红细胞、血浆和胃粘膜组织内的超氧化物歧化酶（ＳＯＤ）活性明显地受到抑制，胃织非蛋白巯基物质含量明显减少．胃粘膜和血浆中的丙二醛（ＭＤＡ）明显升高。给于胃痛灵得乐，可防止胃粘膜损伤，使红细胞、血浆及胃粘膜组织内的ＳＯＤ活性增强，胃粘膜组织和ＭＤＡ明显下降。实验结果表明胃痛灵与丽珠得乐可以通过酶和非酶系两大途径清除自由基，起到对胃粘膜的保护作用。
In this paper,the protective mechanism of Weitongling (WTL) and Lizhudele (DeNol) on gastric mucosal lesion were studied,during the development of gastric injury by acidified ethanol (AE ),suproxide dismutase (SOD) activity in red blood cell (RBC),plasma and gastric mucosa markedly restrained,nonproteinsulfhydryl (NPSH) in gastric mucosa markedly decreased, malondialdehyde (MDA) in gastric mucosa and plasma markedly ascended. WTL and DeNol could prevent gastric mucosa from injury induced by AE. SOD activity in RBC .plasma and gastric mucosa markedly promoted NPSH in gastric mucosa markedly increased,MDA in gastric mucosa and plasma markedly desceded. The results suggested that WTL and DeNol may play an important role in the cell defending mechanisom against ihjury of gastric mucosa cell by enzymatic and nonenzymatic way of free radical scavenging activity.
关键词
胃痛灵
巯基物质
超氧化物歧化酶
丽珠得乐
中药
Weitongling
DeNol
Reductive glutathion
Sulfhydryl compounds
Superoxide dismutase
Malondildehyde
