摘要
目的:探讨血必净、乌司他丁联合治疗对脓毒症患者血D-二聚体水平及凝血机制的影响。方法:选择脓毒症患者43例,随机分为试验组(n=20)和对照组(n=23),对照组给予常规治疗+静脉滴注血必净注射液50ml,2次/d;试验组患者在对照组治疗的基础上加用乌司他丁60万U,静脉滴注,2次/d,连用7d。观察2组患者治疗前、后急性生理学与既往健康状况Ⅱ评分及D-二聚体、凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原和血小板计数的变化。结果:D-二聚体在试验组明显下降,并且在治疗3、7、10d与对照组比较,差异有统计学意义(P<0.05),其他凝血功能也有改善。结论:血必净与乌司他丁联合应用可以改善脓毒症患者恶化的全身炎症反应状态和凝血功能,降低脓毒症的病死率。
Objective： To explore the effects of xuebijing and ulinastatin on level of D-Dimer and coagulation function in patients with sepsis. Methods： Forty three patients with sepsis were randomly divided into 2 groups. Patients in control group（n= 23） were given routine therapy ＋ xuebijing injection 50ml two times a day for 7 days,those in treatment group（n = 20） were injected with ulinastatin 600000U two times a day for 7 days on the basis of treatment of control group. The APACHE II score, D-Dimer, APTT, PT, FIB and PLT were observed before and after therapy. Results： Concentration of D-Dimer declined significantly in treatment group,and it showed significant difference 3,7,10 days after treatment compared with those in the control group （P〈0. 05）, the other coagulation function also improved. Conclusions： Combined use of xuebijing and ulinastatin might improve systemic inflammatory response and blood coagulation dysfunction and reduce mortality rate of patients with sepsis.
出处
《内科急危重症杂志》
2010年第3期145-147,共3页
Journal of Critical Care In Internal Medicine
基金
深圳市科技局非资助项目(No:200803008)
关键词
血必净
乌司他丁
脓毒症
凝血功能
Xuebijing Ulinastatin Sepsis Coagulation function
