摘要
目的：评价白细胞和癌细胞体外药敏相关性，并在卵巢恶性肿瘤、宫颈癌中进行临床疗效观察。方法：用ＭＴＴ法体外药敏试验检测卵巢恶性肿瘤、宫颈癌的癌细胞、白细胞对１０种常用化疗药物的敏感性。结果：卵巢恶性肿瘤的白细胞和癌细胞药敏相关性好，无统计学差异；宫颈癌的白细胞在ＤＤＰ等六种药物的敏感率和阳性率非常显著低于癌细胞（Ｐ＜００５～００１）。卵巢恶性肿瘤、宫颈癌病人化疗时尽量选择癌细胞敏感、白细胞不敏感的药物化疗，其有效率与单用癌细胞敏感的药物化疗结果一样好，但前者化疗后白细胞下降程度明显低于后者，（Ｐ＜００５～００１）。结论：白细胞、癌细胞药敏结果为卵巢恶性肿瘤。
To evaluate the correlation of the chemosensitivity in vitro of cancer cells and peripheral blood leukocytes(PBL),to observe the clinical curative effect of the patients with cervical carcinoma or ovarian malignant tumor.Method:The chemosensitivitv of the cancer cells from 30 cases of ovarian malignant tumor and 22 cases of cervical carcinoma,and the PBL from 16 cases of ovarian carcinoma and 12 cases of cervical carcinoma were tested by MTT method for 10 anticancer drugs.Results:The results showed that there were not significant differences in the sensitivity of 10 anticancer drugs betwween the PBL and cancer cells of the patients with ovarian carcinoma,the sensitivity of the PBL of patients the cervical carcinoma with for the DDP 5FU BLM CTX VCR MTX were significantly lower than that of the cancer cells(P<0 05～0 01).As treating the patients with ovarian malignant tumor and cervical carcinoma,its better to choose the anticancer drugs which are sensitive for cancer cells but not for PBL.But the level of WBC dropped after the chemotherapy of the former was significantly lower than that of the latter(P<0 05～0 01).Conclusions:The results of PBL'S chemosensitivity will provide the reference or ideal plan for the chemotharapy of unresectabla patients of the ovarian carcinoma and cervical carcinoma patients the test will provide the further value of research for the correlation of chemosensitivity of PBL and cancer cells in clinical application.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第1期13-15,共3页
Cancer Research on Prevention and Treatment
