摘要
用紫杉醇（Ｔａｘｏｌ）治疗３０例难治性卵巢上皮癌和输卵管癌，每例均为对含顺铂或卡铂在内的多种抗癌药耐药患者（半数病例对５种以上抗癌药耐药），均经体检或影像学确诊。完全缓解４例，占１３％，平均缓解期为５个月。部分缓解８例，占２７％，平均缓解期为３．９个月。毒副反应：白细胞总数Ⅲ度下降占３０％，中性粒细胞数下降Ⅲ＋Ⅳ度者占３０％；超敏反应，见６例用药时出现面部潮红；脱发严重，占１００％；胃肠反应、神经毒性及心、肝、肾毒性等均不严重。紫杉醇对难治性卵巢癌和输卵管癌的疗效肯定，毒副反应不重，是日前治疗耐药性卵巢癌的良好药物。
Abstract From
September 1993 through Mareh 1994,30 cases of refractory carcinoma of
the ovaryand Fallopian tube were treated with Taxol.Complete response
was seen in 4 and partial res-ponse in 8 cases with a response rate
of 40%. The average length of remission was 5 months inCR and 3.9
months in PR. The major toxic side effect was decrease in total white
cell countand in neutrophil count. Apart from flushing of face during
Taxol infusion in 6 patients,no oth-er allergic reaction was
observed.Gastrointestinal,neurologic,liver and renal toxicities
weremild. Taxol is a drug of choice in the treatment of patients with
cancer of the ovary andFallopian tube who are resistant to
conventional chemotherapy.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1995年第2期135-138,共4页
Chinese Journal of Oncology
