摘要
采用ＭＴＴ法检测了人舌鳞状细胞癌ＳＣＣ－２５和ＳＣＣ－９两株细胞对４种临床常用抗癌药物单一用药及联合用药方案的化疗药物敏感性。单一用药的化疗药物敏感性顺序为：顺铂、博莱霉素、氨甲喋呤、５－氟脲嘧啶，以顺铂为主的联合用药化疗方案的抗癌作用明显优于单一用药，并在较低浓度时亦能达到５０％以上的肿瘤生长抑制率。本实验结果对选择临床用药有一定的指导意义。ＭＴＴ法是一种有希望的、值得进一步研究发展的临床肿瘤药敏试验方法。
The present study was carried out to investigate human tongue cancer (SCC 25 and SCC 9 cell line) drug sensitivity using colorimetric (MTT) assay. The results showed that (1) the order of tongue cancer cells (SCC 25 and SCC 9) drug sensitivity was as follows:CDDP, BLM, MTX, 5 Fu; (2) in the combined drug treatment planing groups the anticancer effect was better than that in the single drug treatment groups (P<0.05). The results suggest that the MTT assay is a useful method for a rapid cancer chemosensitivity assay.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1996年第2期148-150,共3页
West China Journal of Stomatology
