摘要
慢性脑低灌注与正常老龄化和Alzheimer病(AD)引起的认知功能障碍有关。双侧颈总动脉永久结扎(2VO)大鼠慢性期的神经病理改变与人类老龄化和AD时慢性脑低灌注很相似,被广泛用来研究慢性脑低灌注对认知功能损害和神经变性疾病的影响。对近年来有关2VO模型研究成果与人类相关疾病的关系进行客观评价,有助于更好地理解"慢性脑低灌注是神经变性疾病的原因"这一观点,有助于理解何以2VO模型为神经变性疾病以及神经保护机制研究合适的实验对象。
Chronic cerebral hypoperfusion is associate with cognitive impairment caused by the normal aging and Alzheimer’s disease.The neurological pathological changes of permanent ligation of bilateral common carotid arteries （2VO） in rats chronic phase are very similar to those of human aging and AD,which are widely used to study the impacts of chronic cerebral hypoperfusion on cognitive impairment and neurodegenerative diseases.In this paper,the relationship between recently research results in 2VO model and human-related diseases are evaluated objectively,which will contribute to a better understanding the view of ＂chronic cerebral hypoperfusion is the cause of neurodegenerative diseases＂,and is also helpful to understand the use of 2VO model for suitable experimental study of neurodegenerative diseases and potential neuroprotective mechanisms.
出处
《中华脑血管病杂志（电子版）》
2010年第3期31-35,共5页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词
慢性脑低灌注
实验研究
双侧颈总动脉永久结扎
Chronic cerebral hypoperfusion Experimental study Permanent bilateral common carotid artery ligation
